The start-up of production and logistics equipment in a production system is embedded in a superior start-up management. This has to manage the different types of ramp-ups in a value-added network efficiently regarding to products, processes and equipment. Planning uncertainties and multifaceted faults increase the equipment manufacturer’s cost and effort substantially, often lead to delays, partially to delayed start-ups, and tie the system manufacturer longer than planned on the ground. Due to these reasons, a holistic and integrated start-up management is required. Thus, the start-up process accelerates and the competitiveness of all involved companies improves significantly.