As a result of continuously increasing economic constraints for the producing sector in Germany due to competitors from low-wage countries, production paradigms are changing substantially. This paradigm shift is characterized by rapidly advancing automation processes. Hence, highly complex Cyber-Physical Production Systems (CPPS) are developed and put into practice. In combination with decreasing numbers of staff and the resulting loss of knowledge, this leads to a deficit of competence required to handle the increasing complexity of CPPS. As a result, a need for innovative assistance systems arises for the support of the remaining employees. The given article describes the challenges and problems and drafts a potential technical solution as well as challenges concerning organization and staff.