The introduction of new Industry 4.0 technologies is changing job characteristics in many manual industrial sectors, especially in production and logistics, through automation and digitization. Depending on the extent and degree of maturity, these changes are perceived differently by employees and can have both positive and negative effects on job satisfaction and motivation. This article uses the example of workplaces in in-house logistics to highlight how their characteristics change as a result of the introduction of Industry 4.0 technologies. It also presents a process model that can serve as a decision-making aid for companies to consider important implications for the successful transformation process and to pursue the human-centric design of manual, technically supported workplaces.