The digital interactions along the value chain pose new challenges for managing information and knowledge. The objectives of this article are to describe the changes in knowledge-based value creation induced by digitalisation and to derive fields of action for knowledge management for Industry 4.0. The “knowledge ladder 4.0” shows how digital technologies can transform strategic and operative knowledge management. Subsequently, we offer a framework for the knowledge-oriented design of dynamic digital organisations that consists of three layers of activities for the operation, reflection and design of knowledge management illustrated with leading questions and case examples in order to promote the productive, responsible and sustainable usage of digital technologies.