This paper focuses on the application of a bee-like autonomous control method to a matrix-like shop floor model with setup times.Apparently present planning and control systems are unable to cope with the new needs for flexiblity and process reliability resulting from dynamics and complexity in the environment. Autonomous control means de-centralized coordination of intelligent logistic objects in a dynamically changing environment. By the aid of a continuous flow simulation the system’s performance will be analyzed in regard to the application effect on throughput times and inventory levels.