The increasing shortage of IT specialists requires lower-skilled employees to be empowered to perform tasks that previously required the involvement of experts. Industry 4.0’s emerging technologies for human-technology interaction and for the digital twin allow the design of intuitive user interfaces, system-independent communication interfaces, and user-specific assistance functionalities to meet this challenge. This paper presents a framework for configuring and monitoring of process flows for different production and logistics systems. By reviewing existing programming approaches, the paper derives requirements for the framework, describes its general architecture and the technical realization of the modular interaction interface. A prototypical implementation validates the presented concept on the example of a cellular conveyor system and a collaborative robot system.