German industrial companies are suffering from an increasing shortage of skilled workers. In order to secure Germany’s existing competitive advantages, suitable solutions have to be carried out to counter this shortage. Technologies in the context of “Industry 4.0” offer promising solutions. Using this technologies, significant productivity improvements as well as higher resource utilization rates can be achieved. However, the main challenge is to identify the right technical solutions for the specific business challenges. In the following, a systematic approach is presented to face these challenges.