Digitization and related technologies extend the possibility of work design. As companies face the challenge of being able to respond to changing market conditions with agility, digital technologies are creating new ways to increase work flexibility in response to the need for better employee work-life balance. It is important to consider both the needs and requirements of employees and companies and to find satisfactory solutions for both sides. The present article describes how flexible work design is currently used in companies and how the technologies of digitization can be classified and brought together. Based on a structured literature analysis on the state of the art of the potential of flexible work, the article shows the synergy effects of cyber-physical systems, cloud computing and the Internet of Things as the basis for a consensual solution of the needs of companies and their employees.