Along with increasing complexity and dynamics the importance of cyber-physical systems in production and logistics also increases. Hence, the BIBA - Bremer Institut für Produktion und Logistik GmbH at the University of Bremen considers the application of cyber-physical systems in logistics. This paper presents the approach for the development of a cyber-physical logistics system. To start we describe the fundamental terms cyber-physical system and cyber-physical production system. Following these definitions we explain the term cyber-physical logistics system. Afterwards we describe the course of action; in particular necessary steps within the development of a cyber-physical logistics system are explained. In detail we present the procedure consisting of requirements analysis, conception and simulation-based evaluation.